VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain.

By Zhenggang Zhang, Li Zhang, Q. Jiang, RuiLan Zhang, Kenneth R. Davies, Cecylia Powers, N. Bruggen, Michael Chopp. Journal of Clinical Investigation, 2000

1,309 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/cef954d3f313ca28972e9edf779c803dacb7f994

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. C. Iadecola

In Molecular Biology

1. David J. Mooney
2. S. Rivest
3. C. Iadecola
4. T. Mabuchi
5. G. D. del Zoppo

In Radiology, Nuclear Medicine and Imaging

1. Bruce R. Rosen
2. C. Iadecola
3. Richard N. Henson

Citations in the corpus

• VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. (2003, neutral): “One major determinant of the effect of VEGF on the ischemic brain (and a likely source of variability in the studies mentioned above) is the prominence of VEGF-induced edema, which is related to VEGF’s ability to enhance vascular permeability (13, 34).”
• The immunology of stroke: from mechanisms to translation (2011, background): “But VEGF administration early after ischemia or in excessive doses may enhance the damag”
• Role of matrix metalloproteinases in delayed cortical responses after stroke (2006, background): “VEGF may have special relevance for cortical recovery in rodent models of strok”
• Mechanisms of ischemic brain damage. (2008, neutral): “…the effect of individual components of the inflammatory cascade can be beneficial depending on the stage of tissue injury, the magnitude of the response and whether the inflammatory component also activates neuroprotective pathways (Bruce et al., 1996; Nawashiro et al., 2000; Zhang et al., 2000).”
• Cerebral Microvessel Responses to Focal Ischemia (2003, background): “…barrier and the microvascular ECM results from the actions of bradykinin (Kamiya et al., 1993; Aschner et al., 1997), VEGF (Abumiya et al., 1999; Zhang et al., 2000), thrombin (Okada et al., 1994a; Aschner et al., 1997), active matrix metalloproteinases (MMPs) (Heo et al., 1999), proteases…”
• Innate immunity: the missing link in neuroprotection and neurodegeneration? (2002, methodology): “Indeed, administration of recombinant human VEGF to rats 48 hours after an ischaemic episode increased angiogenesis in the ISCHAEMIC PENUMBRA and significantly attenuated neurological recover”