Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium.

By M. Derrien, E. Vaughan, C. Plugge, W. D. de Vos. International Journal of Systematic and Evolutionary Microbiology, 2004

1,962 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/cebc4654ea09241c4eb6002a36ce7db34562a04c

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Citations in the corpus

Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model (2012, background): “Besides host immune effectors (Lievin-Le Moal and Servin, 2006), microbial properties, such as mucus adhesion (Roos and Jonsson, 2002) or the ability to degrade host-derived glycans (Derrien et al., 2004), also impact the distinct surface-attached microbial composition, generally characterized by an”
The first 1000 cultured species of the human gastrointestinal microbiota (2014, background): “Akkermansia muciniphila was described in 2004 as a unique human gastrointestinal bacterium that is able to grow on intestinal mucus as a sole carbon source (Derrien et al., 2004).”
The Mucin Degrader Akkermansia muciniphila Is an Abundant Resident of the Human Intestinal Tract (2007, background): “By incorporating mucin in a medium as a major carbon and energy source, we were able to isolate a novel bacterium, Akkermansia muciniphila MucT (6), that belongs to the Verrucomicrobia phylum, a recently recognized division of the Bacteria (9).”
Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice (2016, background): “emerged as an important component of the gut microbial ecosystem.(19) It accounts for ≈1% to 3% of the microbial com-”
Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review. (2019, background): “Similarly, Akkermansia muciniphila, which accounts for approximately 1–3% of total gut microflora, induces Tjp1 and Ocln gene expression in addition to counteracting HFD-induced thinning of the SUML, thus preventing increased permeation of luminal substrates and pathogens (158, 159).”
Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples (2012, background): “Bacterial phyla originally thought to be exclusively environmental have recently been observed to possess human host-associated membership [33-36].”
Mucin glycan foraging in the human gut microbiome (2015, background): “In the Verrucomicrobia phylum, Akkermansia muciniphila, a strictly anaerobic Gram-negative bacterial species, was recently identified as a key mucin degrader (Derrien et al., 2004).”
Akkermansia muciniphila and its role in regulating host functions. (2017, methodology): “from a healthy Caucasian female in a specific medium that contained purified mucin as the sole carbon source, using the most probable number approach [10].”
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity (2013, methodology): “Here we investigated the strain that is affected during obesity and type 2 diabetes in humans and rodents (18, 23).”
Microbes inside—from diversity to function: the case of Akkermansia (2012, background): “Remarkably, A. muciniphila is a common inhabitant of the intestine of a broad range of animals that has previously been overlooked because of its inconspicuous cell morphology, small size and specific carbon source requirements (Derrien et al., 2004, 2008; Collado et al., 2007).”
Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet–Induced Metabolic Syndrome (2015, background): “muciniphila is an obligate anaerobe, lacking protection against free oxygen radicals (46); therefore, it is tempting to speculate that strong oxygen radical scavenging capacity of poorly absorbed GP can provide a survival advantage to A.”
Mechanisms and consequences of intestinal dysbiosis (2017, background): “Akkermansia muciniphila, a member of the Verrucomicrobiota phylum, commonly found in the gut microbiota is another microbe specialized in the utilization of intestinal mucins as carbon source [109].”
Phylogenetic distribution of three pathways for propionate production within the human gut microbiota (2014, background): “A. muciniphila is a mucin-degrading bacterium originating from the human gut that produces propionate (Derrien et al., 2004).”