Toll-like receptors in the induction of the innate immune response

By Alan Aderem, R. Ulevitch. Nature, 2000

3,279 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/ce9b6d5ddce74025515447dbf3875cd88594e169

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In Immunology

1. Kevin J. Tracey
2. E. Latz
3. M. Abreu
4. Y. Wu
5. D. Golenbock
6. B. Lee
7. BP Zhou
8. P. Godowski

Citations in the corpus

• Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells (2002, neutral): “intervene therapeutically during sepsis (25, 26).”
• CD40 Signaling in B Cells Regulates the Expression of the Pim-1 Kinase Via the NF-κB Pathway1 (2002, background): “Both the Toll-like receptor 4-containing LPS receptor complex (83) and CD40 interact with TRAF proteins and both activate NF- B as well as ERK, JNK, and p38 MAP kinase.”
• TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion (2010, background): “Tumour necrosis factor-a secretion can be induced by conserved structural elements common to microbial pathogens, such as lipopolysaccharide (LPS), that are bound by Toll-like receptors (TLRs) (Aderem and Ulevitch, 2000).”
• A Dual Role for Microbial Pathogen-Derived Effector Proteins in Plant Disease and Resistance (2002, background): “These PAMPs are also recognized by the innate immune systems of insects and vertebrates (Aderem and Ulevitch, 2000; Akira et al., 2000; Hayashi et al., 2001), and the striking similarities of the molecular basis of immunity in different kingdoms were highlighted in a number of recent reviews (Cohn…”
• Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells1 (2001, background): “E-mail address: Klinman@cber.fda.gov 5 Abbreviations used in this paper: TLR, Toll-like receptor; IRAK, IL-1R-associated kinase; TRAF6, TNFR-associated factor 6; ODN, oligodeoxynucleotides; hTLR9, human TLR9; DN, dominant negative; HA, hemagglutinin; ICD, intracellular domain; ECD, extracellular dom”
• Pulmonary alveolar proteinosis: progress in the first 44 years. (2002, background): “The mRNA levels for the mannose receptor and Toll-like receptor-4 and -2 for LPS [108] also were reduced.”