Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.

By F. Doetsch, I. Caillé, Daniel A. Lim, Jose Manuel García-Verdugo, Arturo Alvarez-Buylla. 1999

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Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “The initial support for this model came from evidence of new neuron generation from retrovirus-based lineage tracing under basal conditions and after antimitotic treatment to eliminate rapidly proliferating neural precursors and neuroblasts (Doetsch et al., 1999; Seri et al., 2001).”
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains (2010, background): “A minimum of 10 coronal sections, throughout the anterior–posterior extent of the SVZ of the lateral ventricle, was assessed for each animal.”
Dividing Precursor Cells of the Embryonic Cortical Ventricular Zone Have Morphological and Molecular Characteristics of Radial Glia (2002, background): “At postnatal stages of cortical development, some radial glial cells transform into subventricular zone astrocytes (Schmechel and Rakic, 1979a), which in the adult have been shown to generate neurons that subsequently migrate into the olfactory bulb ( Doetsch et al., 1999 ).”
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases (2004, background): “The analogous role of the intermediate progenitor cell to that of the transit-amplifying cell observed during neurogenesis in the adult SV”
The potential of neural stem cells to repair stroke-induced brain damage (2009, background): “While the DG is thought to contain only one type of progenitor cells, the SVZ contains four types (type A migrating neuroblasts, type B astrocytes, type C immature precursors and type E ependymal cells) arranged in layers [2, 17, 22 , 94].”
Glial cells generate neurons: the role of the transcription factor Pax6 (2002, background): “and was most likely due to contamination with astrocytes from the adult subventricular zone (SVZ) that act as stem cell”
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma (2008, unknown): “We failed to detect gliomas despite robust SmoM2 activation in forebrain progenitors, including developing neural stem cells and persistent progenitors of the SVZ and cortex expressing GFAP (Doetsch et al., 1999), NG2/Olig2 (Ligon et al.”
Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus (2004, methodology): “SVZ astrocytes not only serve as stem cells in this region (Doetsch et al., 1999), but also ensheathe chains of migrating young neurons (Lois et al.”
Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain (2006, background): “These newly generated neurons are derived from SVZa glial fibrillary acidic protein (GFAP)-positive astrocyte”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “B (2008) ventricles and is largely separated from the cerebrospinal fluid (CSF) by a layer of multi-ciliated ependymal cells.”
Vascular niche for adult hippocampal neurogenesis (2000, background): “4A,B) or glial cell (i.e., GFAP/vimentin-positive, Fig.”
A unified hypothesis on the lineage of neural stem cells (2001, background): “For example, stem cells in the adult vertebrate brain express molecular markers and ultrastructural characteristics of mature gli”