Multiple immuno-regulatory defects in type-1 diabetes.

By A. Kukreja, Giulia Cost, J. Marker, Chenhui Zhang, Zhongsheng Sun, K. Lin-Su, S. Ten, Maureen M Sanz, M. Exley, B. Wilson and 2 more. Journal of Clinical Investigation, 2002

728 citations recorded by the source corpus.

Subfields: Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/cdcbd881594b27a0bb3b14795e61d8511338c493

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In Genetics

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Citations in the corpus

• Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells (2006, result): “Although some studies have demonstrated a reduction in CD4+CD25+ T reg cell numbers in autoimmune conditions (2, 3, 8, 12), others have shown normal or even increased numbers of this same subset of T cells (5, 13–15).”
• CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells (2006, background): “In the present study, we reevaluated T reg cells in patients with T1D as compared with normal individuals.”
• Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients1 (2006, result): “(22) that CD4 CD25 T cells are reduced in T1D subjects, it is now ascertained that the frequency of CD4 CD25 /bright T cells in T1D patients is similar to that of healthy controls (12, 13, 23).”
• In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes (2004, background): “The T reg population is reduced in autoimmune-prone animals and patients (8, 39).”
• The unconventional lifestyle of NKT cells (2002, result): “Two studies also showed a decrease in the number and IL-4 production of Vα24 i T cells in diabetics compared with at-risk, non-progressor siblings of the diabetic”
• The PD-1 Pathway in Tolerance and Autoimmunity (2010, background): “Furthermore, effector T cells from T1D individuals may be intrinsically defective.”
• Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy (2004, background): “One recent analysis of human regulatory T cells demonstrated a reduction in their numbers in the PB of newly diagnosed type-1 diabetic patients, suggesting that a deficiency in this subset could be responsible for the breakdown of tolerance in human diabetes (14).”
• Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. (2005, background): “CD4 T-cells were separated into CD25 and CD25 populations by MACS, using anti-CD25 microbeads (Miltenyi Biotech).”
• The biology of NKT cells. (2007, background): “Early claims that humans with type I diabetes exhibited severe NKT cell defects and that their sera had less IL-4 than controls (213, 214) were not confirmed when more specific methodologies became available (38, 215).”
• Going both ways: immune regulation via CD1d-dependent NKT cells. (2004, result): “These findings were supported by 1 study (60), but contradicted by 2 others (61, 62).”
• Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases (2010, neutral): “The initial analyses of T Reg cell numbers (using CD25 expression to define T Reg cells) reported a significant decrease in CD4 + CD25 + T Reg cell numbers in individuals with newly diagnosed or established diseas”
• Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State (2003, background): “There is also some preliminary evidence in humans that type 1 diabetic patients may have decreased blood T reg cell numbers (23).”