The unconventional lifestyle of NKT cells

By M. Kronenberg, L. Gapin. Nature reviews. Immunology, 2002

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Intravascular Immune Surveillance by CXCR6+ NKT Cells Patrolling Liver Sinusoids (2005, background): “]. These lymphocytes co-express NK receptors (e.g., NK1.1) and T cell antigen receptors (TCRs). The largest subset of NKT cells includes thymus-derived CD1d-reactive cells, most of which express a semi-invariant TCR containing Vα14–Jα18 and Vα24–Jα15 rearrangements in mouse and human, respectively, ”
Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function (2003, background): “Although the precise evolutionary niche subserved by NK T cells is not completely clear, the capacity of NK T cells to activate rapid cytokine expression has been exploited to manipulate the outcomes of autoimmunity and cancer (6).”
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. (2004, methodology): “1 TCR NKT cells in all the T-bet / organs studied (Fig- binds the LT receptor on stromal cells (Colucci et al., 2003; Kronenberg and Gapin, 2002; Lian and Kumar,ure 1A) prompted us to further examine this population using GalCer-loaded CD1d tetramers that bind specifi- 2002).”