CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

By Rodolphe Barrangou, C. Fremaux, H. Deveau, Melissa Richards, Patrick Boyaval, Sylvain Moineau, D. Romero, Philippe Horvath. Science, 2007

5,937 citations recorded by the source corpus.

Subfields: Ecology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cd9a15423cda951cc329c682484eeb5902a4a97a

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Citations in the corpus

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. (2013, background): “The CRISPR (clustered regularly interspaced short palindromic repeats) system provides a potential platform for targeted gene regulation (Barrangou et al., 2007).”
Large‐scale image‐based screening and profiling of cellular phenotypes (2017, background): “The CRISPR/Cas9 system is a prokaryotic immune system that can recognize and degrade foreign double-stranded DNA from bacteria, viruses, or plasmids through the introduction of double stranded breaks (42).”
RNA-guided genetic silencing systems in bacteria and archaea (2012, background): “In response to viral and plasmid challenges, bacteria and archaea integrate short fragments of foreign nucleic acid into the host chromosome at one end of a repetitive element known as CRISPR (clustered regularly interspaced short palindromic repeat”
The new frontier of genome engineering with CRISPR-Cas9 (2014, positive): “provided the first experimental evidence of CRISPRCas–mediated adaptive immunity (45).”
Seed Transmission of Tobamoviruses: Aspects of Global Disease Distribution (2017, background): “The viral RNA is processed into small interfering RNA (siRNA) by a drosophila Dicerlike enzyme, which is then incorporated into RNA-induced silencing complex (RISK) that degrades RNAs with sequence similarity to the siRNAs.”
Diversity, Activity, and Evolution of CRISPR Loci in Streptococcus thermophilus (2007, methodology): “thermophilus has been demonstrated previously (2).”
Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System (2013, background): “The type II CRISPR/Cas9 system (clustered regularly interspaced short palindromic repeats/CRISPR-associated) is used by bacteria as an RNA-guided defense system against invading viruses and plasmids (Barrangou et al., 2007; Ishino et al., 1987).”
New CRISPR-Cas systems from uncultivated microbes (2016, methodology): “Metagenomic samples from three different sites were analyzed: (1) Acid mine drainage (AMD) samples collected between 2006 and 2010 from the Richmond Mine, Iron Mountain, California36,37 (2) Groundwater and sediment samples collected between 2007 and 2013 from the Rifle Integrated Field Research (IFR”