Cleavage of Scarecrow-like mRNA Targets Directed by a Class of Arabidopsis miRNA

By C. Llave, Zhixin Xie, Kristin D. Kasschau, James C. Carrington. Science, 2002

1,693 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/cd7d9d680deba8554fb40398dfae4e143e122d59

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. David P. Bartel
2. Phillip D. Zamore
3. V. Narry Kim
4. Jian‐Kang Zhu
5. Olivier Voinnet
6. Xuemei Chen
7. H. Vaucheret
8. Thomas Tuschl

In Plant Science

1. David P. Bartel
2. Jian‐Kang Zhu
3. H. Vaucheret
4. Olivier Voinnet
5. Ramanjulu Sunkar
6. Xuemei Chen
7. Phillip D. Zamore
8. Michael J. Axtell

Citations in the corpus

• Computational identification of plant microRNAs and their targets, including a stress-induced miRNA. (2004, background): “…near matches (0-3) to the miRNAs of these 81 loci (Figure 1A, step 9).precisely to the nucleotide that pairs with the tenth nucleotide of the miRNA (Llave et al., 2002b; Kasschau et After manual inspection for potential hairpin-like sec- ondary structures, this identified six additional loci…”
• Nitrate-responsive miR393/AFB3 regulatory module controls root system architecture in Arabidopsis thaliana (2010, methodology): “2B) 2 h after KNO3 treatment using a modified RNA ligase-mediated 5′ rapid amplification of cDNA ends (RLM-RACE) procedure (28, 32).”
• Novel and Stress-Regulated MicroRNAs and Other Small RNAs from Arabidopsis (2004, methodology): “…2003a; Bartel and Bartel, 2003; Bartel, 2004). miRNAs are known to silence genes posttranscriptionally by targeting cognate mRNAs for degradation (Llave et al., 2002a; Palatnik et al., 2003; Tang et al., 2003) or translation repression (Lee et al., 1993; Reinhart et al., 2000; Aukerman and…”
• Computational prediction of miRNAs in Arabidopsis thaliana. (2005, background): “2003) and some confirmed experimentally (Llave et al. 2002; Aukerman and Sakai 2003).”
• The microRNAs of Caenorhabditis elegans. (2003, background): “2002), and the plant miR171 and miR165/166 have been shown to specify cleavage of their mRNA targets (Llave et al. 2002b; Tang et al. 2003).”
• MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5′ region (2004, background): “MicroRNAs are also found in plants (Llave et al, 2002a; Park et al, 2002; Reinhart et al, 2002), where they appear to be predominately involved in directing the repression of genes involved in development (Rhoades et al, 2002; JonesRhoades and Bartel, 2004).”
• DNA methylation mediated by a microRNA pathway. (2010, background): “However, plant miRNAs repress their target gene expression primarily through mRNA cleavage (Llave et al., 2002; Voinnet, 2009), with a subset of them also repressing translation (Aukerman and Sakai, 2003; Brodersen et al., 2008; Chen, 2004; Dugas and Bartel, 2008; Gandikota et al., 2007; Lanet et…”
• Computational identification of Drosophila microRNA genes (2003, background): “Interestingly, perfect or near-perfect target complementarity is associated with mRNA degradation [24-26], similar to the effects of siRNA, whereas imperfect base-pairing is associated with regulation by translational inhibition [6,27].”
• Functions of microRNAs and related small RNAs in plants (2006, background): “mRNA cleavage seems to be the predominant mechanism of miRNA-guided regulation in plants, based on the detection of cleavage products and on the reduction of steady-state levels of full-length mRNAs in plants overexpressing the corresponding miRN”
• Viral RNA silencing suppressors inhibit the microRNA pathway at an intermediate step. (2004, methodology): “Accumulation of SCL6-IV full-length mRNA (“a” form) relative to the 3 cleavage product (“b” form) was represented as a ratio as described (Llave et al. 2002b).”
• microPrimer: the biogenesis and function of microRNA (2005, background): “Upon binding to their mRNA targets, the miRNA-containing RISCs function as endonucleases, cleaving the mRNA (Llave et al., 2002; Tang et al., 2003).”
• miR-148 targets human DNMT3b protein coding region. (2008, background): “In plants, most described miRNAs bind the protein coding sequence (CDS) of their target mRNAs with very highsequence complementarity, and this induces translational repression or RNA degradation in a way similar to RNA interference (Llave et al. 2002; Rhoades et al. 2002; Chen 2004).”
• Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “However, it is now appreciated that some endogenous miRNAs in both plants and metazoans direct endonucleolytic cleavage (Llave et al. 2002; Yekta et al. 2004; Allen et al. 2005).”