In Search of the In Vivo Identity of Mesenchymal Stem Cells

By L. da Silva Meirelles, A. Caplan, Nance B. Nardi. Stem Cells, 2008

1,092 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/8a2233bd3b43a0ec030609ed60b9abdb013db52c

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In Genetics

In Molecular Biology

A. Caplan

In Surgery

Citations in the corpus

Mesenchymal stem cells: mechanisms of inflammation. (2011, background): “Other investigators (22) have reported that in the collagen-induced model of arthritis, mice infused with MSCs have increased numbers of CD4+CD25+ cells that express FoxP3 and therefore have a Treg phenotype.”
Mesenchymal stem cell homing: the devil is in the details. (2009, neutral): “In addition to the passage number, confluency of the passaged cells, site of isolation, and properties of the media and incubation environment, it is critical to consider the heterogeneity in MSC surface receptor expression and resulting MSC behavior that has been observed both within and between st”
Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells (2012, neutral): “The prevailing view is that all MSCs, irrespective of their in vivo source, are of a perivascular origin and may be regarded as a subset of pericytes (subendothelial cells that lie on the abluminal side of blood vessel lining) [29,30].”
All MSCs are pericytes? (2008, background): “A second function of the MSC/pericyte in settings of focal injury has recently been outlined by my colleagues and me (da Silva Meirelles et al., 2008) and focuses on the fact that MSCs secrete huge amounts of bioactive molecules that contribute to immunomodulatory functions and, separately, offer so”
Mechanisms involved in the therapeutic properties of mesenchymal stem cells. (2009, background): “Chemoattractant CCL2 (MCP-1) Reviewed in [10]”
Why are MSCs therapeutic? New data: new insight (2009, background): “Angiogenesis is brought about by MSC secretion of bioactive factors, such as VEGF, and by the stabilization of newly forming vessels by the repositioning of the MSC into its pericyte role as a perivascular cell [49,54].”