Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

By C. Henchcliffe, M. Beal. Nature Clinical Practice Neurology, 2008

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Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease (2012, background): “In particular, increased PD risk has been linked to mutations in α-synuclein, parkin, PINK1, DJ-1, and LRRK2, all of which have been related to mitochondria [136].”
Metals, oxidative stress and neurodegenerative disorders (2010, positive): “Mutations in PINK1 (PTEN-induced putative kinase) gene are the second most common cause of autosomal recessive, early onset Parkinsonism following the parkin mutations [115].”
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences (2012, neutral): “…pathways that converge at mitochondria (reviewed in Abou-Sleiman et al , 2006; Lin and Beal, 2006; Mandemakers et al , 2007; Bogaerts et al , 2008; Henchcliffe and Beal, 2008; Schapira, 2008; Vila et al , 2008; Van Laar and Berman, 2009; Bueler, 2010; Burbulla et al , 2010; Winklhofer and Haass,…”