Searching for genetic determinants in the new millennium

By N. Risch. Nature, 2000

1,981 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cca1f44b6ceeb2a9bd5b68e094507976fb9149e6

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In Genetics

Citations in the corpus

Genomewide scans of complex human diseases: true linkage is hard to find. (2001, background): “…(Haines et al. 1996; Kuokkanen et al. 1997), rheumatoid arthritis (Cornelis et al. 1998), psoriasis (Nair et al. 1997; Trembath et al. 1997; Samuelsson et al. 1999; Lee et al. 2000a), inflammatory bowel (Hampe et al. 1999; Rioux et al. 2000), and asthma/ allergy (Daniels et al. 1996; The…”
Haplotype blocks and linkage disequilibrium in the human genome (2003, background): “, and in association studies in which disease variants can be detected through the presence of association at nearby site”
Assessing genetic potential in germplasm collections of crop plants by marker-trait association: a case study for potatoes with quantitative variation of resistance to late blight and maturity type (2004, background): “The association between a molecular haplotype and disease phenotype will allow genetic risk assessment and, eventually, personalized therapy Schafer and Hawkins 1998; Risch 2000 .”
Mapping of quantitative trait loci controlling adaptive traits in coastal Douglas-fir. IV. Cold-hardiness QTL verification and candidate gene mapping (2005, background): “Association genetics was pioneered in humans ( Risch 2000; Cardon and Bell 2001), has been applied in maize (Thornsberry et al. 2001), and is anticipated to be widely applied to plants in the near future (Rafalski 2002; Neale and Savolainen 2004).”
Genetic basis for individual variations in pain perception and the development of a chronic pain condition. (2005, methodology): “As it has been discussed by Risch (20), alleles with polymorphic frequencies ,0.”
Methods for genotyping single nucleotide polymorphisms. (2003, background): “The availability of an ultra-high density SNP map opens the possibility of studying by association genetic factors important in complex genetic traits in the human, taking advantage of the fact that genetic markers in close proximity to mutant genes may be in linkage disequilibrium (LD) to them (21,”
Association study designs for complex diseases (2001, background): “Despite these known limitations, the power of association analysis to detect genetic contributions to complex disease can be much greater than that of linkage studie”
Research review: Polygenic methods and their application to psychiatric traits. (2014, background): “The contribution of these genetic variants to variance can be calculated on the liability scale (Risch, 2000; Sham, 1998; So, Gui, Cherny, & Sham, 2011) to allow direct comparison of the contribution to risk of each locus on the same scale as heritability is reported.”
Integrating Case‐control and TDT Studies (2005, methodology): “With the improvements in molecular techniques for high-throughput genotyping of single nucleotide polymorphisms (SNPs), the gene-association method is widely anticipated to unveil the genetic basis of complex diseases (Risch, 2000; Cardon & Bell, 2001; Cardon & Zondervan, 2004).”
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease (2011, methodology): “The fraction of additive variance was calculated using a liability threshold mode”
How malaria has affected the human genome and what human genetics can teach us about malaria. (2005, background): “Large-scale epidemiological studies are needed for the sample sizes required to detect modest effects while testing perhaps a million SNP markers (Risch 2000 ).”
Genome‐Wide Association Analysis Identifies Candidate Genes Associated with Iron Deficiency Chlorosis in Soybean (2011, background): “Association mapping uses the linkage disequilibrium (LD) pattern in a large population of unrelated individuals (Risch, 2000).”
Multiple common variants for celiac disease influencing immune gene expression (2010, positive): “The fraction of additive variance was calculated using a liability threshold mode”