Genomewide scans of complex human diseases: true linkage is hard to find.
By J. Altmüller, Lyle J. Palmer, G. Fischer, H. Scherb, Matthias Wjst. American Journal of Human Genetics, 2001
598 citations recorded by the source corpus.
Subfields: Genetics
View Paper: https://www.semanticscholar.org/paper/e06d497916bc5342f5aca47e44ecc8e5666ec3bb
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In Genetics
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Citations in the corpus
- The allelic architecture of human disease genes: common disease-common variant...or not? (2002, background): “Linkage mapping, which is a powerful tool for finding Mendelian disease genes, often produces weak, and sometimes inconsistent, signals in complex disease studies (4).”
- HEGESMA: genome search meta-analysis and heterogeneity testing (2005, background): “…http://bioinform atics.oxfordjournals.org/ D ow nloaded from many independent teams perform genome scans for the same disease and often the important loci are difficult to discern due to low linkage signals (Altmuller et al., 2001) and/or apparent diversity in the results of different searches.”
- Finding the missing heritability of complex diseases (2009, methodology): “(8) Pooling rare variants for analysis using logical criteria, by addressing the questions: do the different rare variants increase or decrease disease risk? What classes of variants should be pooled? What is the optimal level of MAF for pooling? (9) Improving CNV detection by developing more extens”
- Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. (2003, background): “In particular, twin and adoption studies that suggested substantial genetic influences on the liability to schizophrenia(1) helped create the empirical rationale for numerous ongoing searches to identify the predisposing genetic loci.(2,3) Recently, several groups(4-6) have presented evidence for ge”
- The Ubiquitous Nature of Epistasis in Determining Susceptibility to Common Human Diseases (2003, methodology): “A similar review has been conducted by Altmuller et al. [2002] for 101 genetic linkage studies of 31 different diseases.”