Research review: Polygenic methods and their application to psychiatric traits.
By Naomi R. Wray, Sang Hong Lee, D. Mehta, A. Vinkhuyzen, Frank Dudbridge, C. Middeldorp. 2014
677 citations recorded by the source corpus.
Subfields: Experimental and Cognitive Psychology, Genetics, Psychiatry and Mental health
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In Genetics
Citations in the corpus
- PRSice-2: Polygenic Risk Score software for biobank-scale data (2019, neutral): “…P -value thresholding, known as the “C + T” method [14], and retains the majority of the features of its predecessor [13], including automatic strand flipping, clumping [18], and calculation and evaluation of PRS under few (“fastscore”) or many (“high-resolution scoring”) P -value thresholds.”
- Integrative omics for health and disease (2018, methodology): “In the genomics space, with an individual’s genotype and a data-base of results from GWAS, one can compute a polygenic risk score to assess an individual’s risk of disease 4,77 (for recent reviews on methodology, see REFS 22,78 ).”
- Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses (2019, neutral): “This has conceptual similarities to clumping, used in polygenic risk score construction to select the strongest signal in each LD-independent set of SNPs [56], and to the division of the genome into LD-independent blocks, [57] but differs to each.”