Divergence of melanocortin pathways in the control of food intake and energy expenditure.

By N. Balthasar, L. Dalgaard, Charlotte E. Lee, Jia Yu, H. Funahashi, Todd D. Williams, Manuel Ferreira, V. Tang, Robert A. McGovern, Christopher D. Kenny and 10 more. Cell, 2005

1,112 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/0532165fab230365af8c01a2164b12fc2bb8cf25

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Bryan L. Roth
2. Bradford B. Lowell
3. C. Ye
4. M. Krashes
5. J. Elmquist
6. Haiming Cao
7. G. Hotamışlıgil

In Nutrition and Dietetics

1. Bradford B. Lowell
2. Bryan L. Roth
3. J. Elmquist

In Physiology

1. B. Spiegelman
2. E. Rosen
3. Bradford B. Lowell
4. G. Hotamışlıgil
5. Haiming Cao
6. R. Scarpulla
7. P. Seale
8. A. Chawla

Citations in the corpus

• Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons (2011, positive): “, 1999), its receptor, MC4R (Balthasar et al., 2005; Huszar et al., 1997), and in mice with ablation of POMC neurons (Xu et al.”
• A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior (2015, positive): “We verified effective transduction of KORD in a Credependent manner in a variety of neurons, including the substantia nigra (SN) and the ventral tegmental area (VTA) of vesicular GABA transporter (VGAT)-ires-Cre mice (Figs 2B and 2C), the paraventricular hypothalamus (PVH) of single-minded1 (SIM1)-C”
• Melanocyte biology and skin pigmentation (2007, background): “Other melanocortin family member receptors are found on various cell lineages — for example, MC4R is expressed in the hypothalamus, where it modulates energy metabolis”
• Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. (2011, methodology): “Expectedly (Huszar et al., 1997; Balthasar et al., 2005) loxTB MC4R animals demonstrated marked hyperglycemia and hyperinsulinemia in comparison to wild-type mice (Figure 5A– D).”
• The Human Obesity Gene Map: The 2005 Update (2006, background): “Expressed in paraventricular hypothalamic nucleus and subpopulation of amygdala Prevents 60% of obesity, rescues hyperphagia but not reduced energy expenditure of Mc4r-deficient mutant mice (468)”
• Adipocytes as regulators of energy balance and glucose homeostasis (2006, background): “Leptin-dependent effects on food intake and energy expenditure ultimately diverge in the central nervous system (CNS), partly at the level of melanocortin MC4 receptor signallin”