S100 proteins expressed in phagocytes: a novel group of damage‐associated molecular pattern molecules

By D. Foell, H. Wittkowski, T. Vogl, J. Roth. Journal of Leukocyte Biology, 2007

884 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cc2670dbdaf6edea30dbfad17fcd70ac6c9b8d08

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Citations in the corpus

The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis. (2016, background): “granulin B) are members of the calcium-binding S100 family expressed in phagocytic cells.(42) S100A8 and S100A9 rapidly”
Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans (2009, background): “S100A8 and S100A9 belong to the large group of S100 calcium-binding proteins and form a heterodimer, calprotectin, which is abundant in neutrophils, monocytes and early differentiation stages of macrophages [27].”
The inflammatory response to cell death. (2008, background): “These proteins are found in granulocytes, monocytes, macrophages, keratinocytes and, in inflammatory conditions, also epithelial cells (53).”
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “Heterodimeric S100A8/A9 complexes are calcium-binding proteins that are released by neutrophils and activated monocytes (91).”
Functions of S100 Proteins (2012, background): “Some, such as the S100A8/S100A9 complex and S100B are considered biomarkers for particular disease processes [74,105,141-147] (also see below).”
Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function (2010, background): “The precise mechanism of this effect is not clear, but it was suggested that the S100A9 and S100A8 heterodimer might participate in the formation of the NADPH oxidase (Nox2) complex that is responsible for production of ROS in myeloid cells.”
DAMPening Inflammation by Modulating TLR Signalling (2010, background): “Furthermore, the S100 family of calcium binding proteins have long been reliable biomarkers of inflammation in a wide variety of diseases; for example, both MRP8 and MRP14 levels in the RA synovium and synovial fluid correlate with disease activity to a degree greater than levels of C-reactive prote”
Damage-Associated Molecular Patterns in Inflammatory Diseases (2018, background): “Although S100 proteins have various functions, which include cell proliferation, differentiation, migration, and energy metabolism under healthy conditions (17), they also act as DAMPs by interacting with TLR2, TLR4, and RAGE after they are released from phagocytes (18).”
The endogenous Toll–like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer (2009, background): “Over the past 15 years, S100A8/S100A9 has evolved as an excellent biomarker of inflammatory processes, especially in rheumathoid arthritis, juvenile idiopathic arthritis, and inflammatory bowel disease [7, 13].”
The sterile inflammatory response (2010, neutral): “HMGB1 (39), SAP130 (40), IL-1α (37), IL-33 (41), DNA (42, 43), S100 proteins (44), heat shock proteins (45, 46) and others (47).”