The endogenous Toll–like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

By J. Ehrchen, C. Sunderkötter, D. Foell, T. Vogl, J. Roth. Journal of Leukocyte Biology, 2009

847 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/8cdb0efbd643b316d02c66fafb8751f7a824a20c

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In Immunology

1. Arturo Zychlinsky
2. V. Brinkmann
3. G. Núñez
4. N. Inohara
5. C. Goosmann
6. P. Kubes
7. V. Papayannopoulos
8. N. Borregaard

In Molecular Biology

1. G. Núñez
2. M. Zeng
3. N. Inohara
4. C. Goosmann
5. V. Brinkmann
6. Arturo Zychlinsky
7. T. Kanneganti
8. M. Lamkanfi

In Pulmonary and Respiratory Medicine

1. Arturo Zychlinsky
2. V. Brinkmann
3. P. Kubes

Citations in the corpus

• Functions of S100 Proteins (2012, background): “In these circumstances, they are generally secreted, and may function as extracellular alarmins or damageassociated molecular pattern factors that principally mediate functions of the innate and adaptive immune systems, stimulate cancer cell locomotion and/or participate in tissue repair [5-13].”
• Mechanisms of inflammation-driven bacterial dysbiosis in the gut (2016, positive): “Elevation of Calprotectin in the extracellular fluids of patients with inflammatory disorders, such as rheumatoid arthritis and vasculitis, renders calprotectin a marker for inflammation.(91) In response to inflammation in the gut, transmigration of neutrophils into the intestinal lumen leads to mas”
• Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans (2009, background): “Indeed, this complex is now used as a marker for inflammation [34].”