Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt+ Cells

By G. Eberl, Dan R. Littman. Science, 2004

483 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cbd327a4073d4a048b54fef30398dbc5d251b6ec

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In Immunology

Citations in the corpus

The microbiota regulates type 2 immunity through RORγt+ T cells (2015, methodology): “Foxp3 mice were purchased on a NOD/ShiLt background (The Jackson Laboratory) and crossed to Rorc(γt) mice (The Jackson laboratory) and to Stat3 mice (50) on a C57BL/6 background, as were Rorc(γt) mice (51).”
IL-17 family cytokines and the expanding diversity of effector T cell lineages. (2007, background): “To examine the role of RORγt in T cell development and lymphoid organogenesis, Littman and colleagues generated mice with the coding sequence for green florescent protein (GFP) knocked into the initiation site of RORγt translation, thereby reporting cells activating this locus while knocking out exp”
CD4+ lymphoid tissue inducer cells promote innate immunity in the gut (2010, background): “After birth, LTi cells persist in the secondary and mucosa- associated lymphoid tissues of adult humans and mice (Cupedo 122 Immunity 34, 122–134, January 28, 2011 ª2011 Elsevier Inc. et al., 2009; Eberl and Littman, 2004; Tsuji et al., 2008).”
The Microbiome in Infectious Disease and Inflammation (2012, unknown): “LTi-like cells are also present in the adult intestine and gut-associated lymphoid tissue (GALT) as RORγt+lin−c-kit+IL-7R+ cells (197).”
Progressive loss of RORγt expression confers distinct functional fates to natural killer cell receptor-expressing RORγt+ innate lymphocytes (2010, unknown): “As previously reported, RORgt expression serves as a faithful marker of intestinal LTi-like cells in adult mice (Eberl and Littman, 2004).”