Consequences of cellular cholesterol accumulation: basic concepts and physiological implications.

By I. Tabas. Journal of Clinical Investigation, 2002

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Role of cholesterol and lipid organization in disease (2005, background): “The activity of ACAT is regulated by cholesterol level”
Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword? (2007, positive): “…the Fas death pathway and the mitochondrial cell-death pathway may contribute to macrophage apoptosis, accumulating evidence suggests that depletion of calcium stores in the ER and subsequent activation of the UPR is the dominant driving force in cholesterol-induced macrophage death (135, 136).”
Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. (2005, background): “Atherogenic risk is strongly dependent upon plasma lipoproteins containing ApoB100,(66) which facilitates the accumulation of cholesterol and other lipids into the arterial wall by multiple mechanisms.(67,68) Although consumption of fructose can increase triglycerides and ApoB, the effects of fructo”