Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling
By Joseph W. Thornton, Eleanor F. Need, D. Crews. Science, 2003
651 citations recorded by the source corpus.
Subfields: Biotechnology, Cellular and Molecular Neuroscience, Ocean Engineering
View Paper: https://www.semanticscholar.org/paper/cb4f09dcf20c7700c3a5c1c5e2ca4c981182ce68
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In Biotechnology
In Cellular and Molecular Neuroscience
In Ocean Engineering
Citations in the corpus
- FastML: a web server for probabilistic reconstruction of ancestral sequences (2012, background): “Such an approach was successfully applied to study the evolution of the ancestral archosaur visual pigment rhodopsin (2) and the evolution of the steroid receptor (3) to name a few.”
- Enzyme promiscuity: a mechanistic and evolutionary perspective. (2010, background): “The reconstruction and receptors (154, 155), as well as laboratory evolution of protein-protein interfaces (149), www.annualreviews.org • Enzyme Promiscuity 493 idea of generalist progenitors.”
- Possible roles of sex steroids in the control of reproduction in bivalve molluscs (2007, methodology): “Surprisingly, however, recent evidence suggests that such “estrogen receptors” are constitutively active and do not bind estrogen (Kajiwara et al., 2006; Keay et al., 2006; Matsumoto et al., 2007; Thornton et al., 2003 ).”
- Mechanistic approaches to the study of evolution: the functional synthesis (2007, background): “Similarly, Thornton's group has found that several other hormone–receptor pairs also evolved when new molecules co-opted old molecules that once had different function”
- Turning a hobby into a job: How duplicated genes find new functions (2008, background): “When an ancestral steroid receptor was resurrected, it was found to be most responsive to oestrogen compounds and much less responsive to other modern steroids, including progesterone, testosterone, and cortiso”
- Consensus protein design (2016, background): “Multiple sequence alignments (MSAs) and phylogenetic analyses have become standard tools for exploring sequence conservation (Steipe et al., 1994) and ancestral relationships (Pauling et al., 1963; Yang et al., 1995; Thornton et al., 2003; Thornton, 2004) amongst protein homologues.”
- Principles for modulation of the nuclear receptor superfamily (2004, background): “Nevertheless, it has to be emphasized that the phylogenetic analysis of the nuclear receptors in the available complete genome sequences of metazoans, as well as the identification of an oestrogen receptor orthologue in a mollusc (non oestradiol-binding), strongly indicates that liganded receptors, ”