Metabolic Regulation of Brain Aβ by Neprilysin

By N. Iwata, S. Tsubuki, Y. Takaki, K. Shirotani, B. Lu, N. Gerard, C. Gerard, E. Hama, Hahn‐Jun Lee, T. Saido. Science, 2001

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Alzheimer’s Disease and the β-Amyloid Peptide (2010, neutral): “responsible for most Aβ degradation [51–55].”
APP mouse models for Alzheimer's disease preclinical studies (2017, neutral): “However, because A b degradation declines with aging potentially due to a decrease in the major A b -degrading enzyme neprilysin (Iwata et al , 2001, 2002; Hellstro¨m-Lindahl et al , 2008) and because A b clearance is decreased in SAD patients (Mawuenyega et al , 2010), A b deposition in SAD is…”
ApoE promotes the proteolytic degradation of Abeta. (2008, background): “Mice in which Nep or Ide have been genetically inactivated exhibit higher Aβ levels and enhanced plaque deposition in the brain (Farris et al., 2003; Farris et al., 2007; Iwata et al., 2001).”
The role of microglia in amyloid clearance from the AD brain (2010, background): “Deletion of the Nep gene or inhibition of NEP activity with the metalloprotease inhibitor phosphoramidon were shown to increase Aβ levels in mouse models of AD (Eckman et al. 2006; Farris et al. 2007; Iwata et al. 2001).”
Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders (2011, background): “In brain, amyloid-β is enzymatically degraded by neprilysi”