MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation

By Ruirui Ji, Yun-hui Cheng, Junming Yue, Jian Yang, Xiaojun Liu, He Chen, D. Dean, Chunxiang Zhang. Circulation Research, 2007

950 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cb19d1157f4e2405c2827f3d257f1f1299893438

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In Cancer Research

1. Galina Gabriely
2. Danish H Sayed
3. M. Abdellatif
4. Manel Esteller
5. Anna M. Krichevsky
6. E. Olson

In Molecular Biology

1. Galina Gabriely
2. Danish H Sayed
3. M. Abdellatif
4. M. Krüger
5. Thomas Braun
6. Manel Esteller
7. Rui Wang
8. Anna M. Krichevsky

Citations in the corpus

• Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. (2012, background): “The overexpression of MiR-21 was abundant in rat carotid arteries after angioplasty (276) and in proliferative human aorta SMCs as well as injured mouse carotid arteries (733).”
• Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. (2009, background): “Transitions of the phenotypic state of VSMCs play a key role in the repair of vascular injuries and in the development and/or progression of atherosclerosis, which is also reflected by the rapid downregulation of multiple miRNAs during neointima development after vascular injury (24).”
• miR-21: a small multi-faceted RNA (2008, background): “Down-regulation of aberrantly expressed miR-21 also reduces neointima formation in rat carotid artery after angioplasty by affecting both proliferation and apoptosis of vascular smooth muscle cells (VSMCs) [21].”
• Non-coding RNAs in human disease (2011, background): “As with heart failure, an miRNA expression signature distinguishes the vascular lesion from healthy tissu”
• MicroRNAs in development and disease. (2011, background): “miR-21, which is a ubiquitously expressed prosurvival miRNA, was shown to inhibit PTEN expression under these conditions (275, 416, 417).”
• MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation (2009, neutral): “performed according to an established protocol (1-3).”