Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans

By Y. Doyon, W. Selleck, William Arbuthnot Sir Lane, Song Tan, J. Côté. Molecular and Cellular Biology, 2004

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Link communities reveal multiscale complexity in networks (2009, background): “There are three major communities, all three are related to the transcription process, identiﬁed as the mediator complex, NuA4 HAT complex, and SAGA complex, 29–31 respectively.”
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes (2009, background): “Tip60 is the catalytic subunit of an evolutionarily conserved complex, which contains at least 12 subunits, including TRRAP (Doyon et al., 2004).”
The interplay of histone modifications – writers that read (2015, neutral): “The function of these accessory proteins remains unclear, although”
Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes (2013, neutral): “The human ortholog of the Swr1 complex, TIP60, has combined chromatin remodeling and histone acetyltransferase activities (Doyon et al., 2004), and the human ortholog of Fun30 has profound effects on the re-establishment of histone modiﬁcations following DNA replication (Rowbotham et al., 2011).”
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. (2006, background): “(A slight defect in p21 transcription was observed upon TIP60 depletion, consistent with suggestions that TIP60 is required for the acetylation of histones at the p21 promoter (Doyon et al., 2004).”