Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation.

By C. Brooks, W. Gu. Current Opinion in Cell Biology, 2003

803 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/def888fc9625ccff71c3f045c3cf9a408e47bfeb

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Citations in the corpus

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. (2005, background): “Oxidative stress causes extensive posttranslation protein modifications, including acetylation and ubiquitination (Brooks and Gu, 2003).”
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase (2004, background): “Since acetylation of p53 at lysine 382 by CBP/p300 is critical for p53 stabilization and heightened transcriptional activation, SIRT1-mediated deacetylation cripples p53-induced apoptosis (Brooks and Gu, 2003).”
Identification, Analysis and Prediction of Protein Ubiquitination Sites (2010, background): “94,95 Therefore, lysine 305 in p53 is a good candidate for experimental verification.”
p53 ubiquitination: Mdm2 and beyond. (2006, background): “…phosphorylation and acetylation remain the major posttranslational modifications that occur on p53 and Mdm2 during times of cell stress (Brooks and Gu, 2003), although additional modifications have also been identified under certain conditions, including sumoylation, neddylation, and…”
p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure–Function Continuum Concept (2016, background): “In response to different types of stress, the acetylation levels of p53 are increased, which is associated with the activation of this protein, leading to the recruitment of various cofactors needed for its promoter specific transcriptional activity [214,215].”
Acetylation is indispensable for p53 activation. (2008, background): “p53 Acetylation Is Essential for Inhibiting the p53-Mdm2 Complex Formation During the DNA Damage Response Both phosphorylation and acetylation of p53 are commonly induced upon many types of stress (Brooks and Gu, 2003).”
The Roles of Post-translational Modifications in the Context of Protein Interaction Networks (2015, background): “Indeed, the combined action of these three PTMtypes has been described in selected cases as, for example, for the protein p53 [20].”
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas (2006, background): “) that p53 post-translational modifications at these conserved residues have a crucial role in p53 stabilization and activatio”
Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies (2016, background): “Activation of wildtype (wt) p53 occurs in response to genotoxic stress essentially through posttranslational modifications, such as acetylation and phosphorylation, resulting in protein stabilization (by escape from proteasome-mediated degradation) and nuclear localization leading to binding to sequ”