Identification of fibroblast heterogeneity in the tumor microenvironment
By H. Sugimoto, T. Mundel, M. Kieran, Raghu Kalluri. Cancer Biology & Therapy, 2006
705 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/caf462f72d2c3d9abcaad7ded178c2e090387b15
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In Cancer Research
In Molecular Biology
In Oncology
Citations in the corpus
- Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. (2010, background): “Although the myofibroblast marker a-SMA is commonly used to identify CAFs, it is intracellular, and it is not certain that all CAFs are a-SMA positive (Sugimoto et al., 2006).”
- Stroma Cells in Tumor Microenvironment and Breast Cancer (2012, neutral): “The results indicated that α-SMA, PDGFR-β, and NG2 (chondroitin sulfate proteoglycan) significantly overlap each other in identifying a mixed population of fibroblasts (CAFs, myofibroblasts, pericytes, and vascular smooth muscle cells), while αSMA or vimentin alone is not a suitable marker for CAFs,”
- The tumor microenvironment at a glance (2012, background): “Most TAMs have an IL10high, IL-12low phenotype with expression of the mannose receptor and scavenger receptor class A (SR-A, also known as SCARA) (Biswas and Mantovani, 2010; Mantovani, 2011; Mantovani et al., 2002).”
- CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. (2018, neutral): “Different CAF populations that secrete distinct profiles of cytokines have been identified in a variety of cancers (Öhlund et al., 2017; Sugimoto et al., 2006).”
- Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer. (2018, neutral): “Consistently, aSMANeg PDGFRaPos fibroblasts have been identified in both normal and neoplastic skin (Sugimoto et al., 2006; Erez et al., 2010), suggesting that aSMANeg PDGFRaPos and CAF-S3 cells could share some features.”
- Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth (2015, background): “derived from several cell types, and are therefore heterogenous [8,16] (Figure 1).”
- Fibroblast heterogeneity in the cancer wound (2014, neutral): “1; Sugimoto et al., 2006).”