Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture

By W. Rombouts, R. Ploemacher. Leukemia, 2003

599 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/cad7089f2ac2c178dd9007689fdefcf35cba409b

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In Genetics

1. T. Suda
2. Frank Barry

In Hematology

1. T. Suda

In Oncology

1. T. Suda

Citations in the corpus

• Mesenchymal stem cell homing: the devil is in the details. (2009, unknown): “Freshly isolated MSCs have been shown to display enhanced homing ability compared to their cultureexpanded counterparts (Rombouts and Ploemacher, 2003).”
• Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow (2009, background): “As has been reported (Rombouts and Ploemacher, 2003), we found that cultured MSCs lost their homing ability.”
• Aging of mesenchymal stem cells. (2006, background): “Interestingly, the efficiency of differentiating into local tissue (‘homing’) of transplanted MSC was found to be severely decreased following culture (Rombouts and Ploemacher, 2003), casting fundamental doubts on the applicability of in vitro data to differentiation studies.”
• Immunobiology of mesenchymal stem cells (2013, background): “Indeed, compared with freshly isolated MSCs, cells maintained in culture display impaired homing ability.(98,99) Related to this, CXCR4, a receptor for SDF-1that presents at high levels in the bone marrow and ischemic tissues, always disappears from the surface of MSCs after culture.”
• Mesenchymal stem cells: clinical applications and biological characterization. (2004, background): “Homing and expansion of MSCs to the injured host was also elegantly demonstrated by Rombouts and Ploemacher (2003). They showed that in an irradiated host there was both migration and expansion of GFP-expressing syngeneic MSCs in the marrow and spleen.”