An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

By M. Chamaillard, M. Hashimoto, Y. Horie, J. Masumoto, S. Qiu, Lisa Saab, Y. Ogura, A. Kawasaki, K. Fukase, S. Kusumoto and 5 more. Nature Immunology, 2003

1,388 citations recorded by the source corpus.

Subfields: Endocrinology, Immunology

View Paper: https://www.semanticscholar.org/paper/cacd203babd4be917d2c1c82a2fc24fba147e3ac

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In Endocrinology

1. Shizuo Akira
2. G. Núñez
3. P. Sansonetti
4. N. Inohara
5. B. Sinha
6. Martin J. Fraunholz

In Immunology

1. Shizuo Akira
2. T. Mogensen
3. Satoshi Uematsu
4. G. Núñez
5. W. Strober
6. Danyang Li
7. Minghua Wu
8. P. Murray

Citations in the corpus

• A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation (2008, background): “Two NLR family members, Nod1 and Nod2, play an essential role in the recognition of specific bacterial peptidoglycan (PGN)- related molecules (Chamaillard et al, 2003; Inohara et al, 2003; Girardin et al, 2003a, b).”
• Pathogen recognition and innate immunity. (2006, neutral): “NOD1 and NOD2 detect g-D-glutamyl-meso-diaminopimelic acid (iE-DAP) and muramyl dipeptide (MDP), found in bacterial PG, respectively (Figure 4) (Chamaillard et al., 2003; Girardin et al., 2003).”
• LPS, TLR4 and infectious disease diversity (2005, background): “In this context, it is interesting to note that the recently described mammalian Nod proteins have amino acid sequence similarity with plant R proteins, and might therefore form a common mechanism for the intracellular signalling of bacterial infection”
• Caspase functions in cell death and disease. (2013, background): “Both recognize products of bacterial peptidoglycan degradation, with NOD1 binding to mesodiaminopimelic acid derived mainly from Gram-negative bacteria (Chamaillard et al. 2003; Girardin et al. 2003a), and NOD2 detecting the muramyl dipeptide common to both Gram-negative and Gram-positive bacteria (”
• Toll-like receptors in innate immunity. (2004, neutral): “Recent studies have demonstrated that overexpression of NOD1 enables 293 cells to respond to preparations of PGN (56,57).”
• Toll-like receptors and innate immunity (2006, background): “Although initial studies identified LPS as a NOD2 ligand [76], it is well established now that NOD1 and NOD2 recognize peptidoglycan-derived peptides, γ-Dglutamyl-meso-diaminopimelic acid (iE-DAP) [77] and muramyl dipeptide (MDP) [78, 79], respectively.”
• Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance (2014, background): “NOD1 activity is triggered by γ-d-glutamyl-meso-diaminopimelic acid, a unique PGN structures from all Gram-negative and some Gram-positive bacteria (68).”
• Are innate immune signaling pathways in plants and animals conserved? (2005, background): “Nod1 responds to γ- D -iso-glutamyl diaminopimelic acid, and Nod2 responds to muramyl dipeptid”