Notch signaling: control of cell communication and cell fate

By Eric C. Lai. Development, 2004

1,109 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cab337c62ace16d3d19c30ed6d1fb6629d20e3ed

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In Molecular Biology

Citations in the corpus

Off the beaten pathway: the complex cross talk between Notch and NF-κB (2008, background): “Briefly, there are four mammalian Notch receptors (Notch-1, -2, -3, and -4) and five ligands (Jagged-1/-2, Delta-like 1, 3, and 4).(7)”
Biological principles of microRNA-mediated regulation: shared themes amid diversity (2008, background): “This suggested that miRNAs set a threshold activity level for Notch target gene transcription, possibly to ensure that Notch pathway activity is not deployed inappropriately by transcriptional nois”
Signaling cross-talk between TGF-β/BMP and other pathways (2009, neutral): “Simple as it is, the TGF-β/BMP pathway controls a myriad of events, including cell proliferation, differentiation, apoptosis, migration, extracellular matrix (ECM) remodeling, immune functions, and tumor invasion/metastasis [4-8]. On the other hand, the activity and the signaling outcomes of this pa”
RBP-Jκ/SHARP Recruits CtIP/CtBP Corepressors To Silence Notch Target Genes (2005, background): “In fact, we demonstrated that CtIP colocalizes with wild-type SHARP(12-3664) in the nucleus and SHARP lacking a nuclear localization signal (aa 2002 to 3664) in the cytoplasm (Fig.”
Notch signalling in vertebrate neural development (2006, background): “In addition, the quantity of receptors or ligand on the surface is also influenced by feedback loops that exist in both vertebrate and invertebrate systems but are mechanistically not well understoo”
Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “…is important in directing cell fate and cell proliferation during embryonic development, has been shown to contribute to cell transformation in vitro and to the development of human cancers when aberrantly regulated (for review, see Radtke and Raj 2003; Kadesch 2004; Lai 2004; Sjolund et al. 2005).”
MicroRNA functions in animal development and human disease (2005, background): “The Notch signalling pathway is an evolutionary conserved signal transduction cascade that is required for patterning and normal development (Lai, 2004).”