A Direct Role for Dual Oxidase in Drosophila Gut Immunity

By Eun-Mi Ha, Chun‐Taek Oh, Y. Bae, W. Lee. Science, 2005

807 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/caa7d752de1592260f135c1cbd4bddfe102c9041

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In Immunology

In Insect Science

Citations in the corpus

Multiorganismal Insects: Diversity and Function of Resident Microorganisms (2014, background): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript sensitive to ROS induced by some members of the gut microbiota in their phlebotomine sand fly vector (Lutzomyia longipalpis) (32).”
Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. (2009, background): “…consequence of the ROS burst that peaks 1 hr after Ecc15 infection and is consistent with a previous study demonstrating that ROS production by the NADPH oxidase Duox is essential for elimination of ingested bacteria and requires tight regulation to prevent damage to gut cells (Ha et al., 2005).”
Amino acids and immune function (2007, background): “Notably, a lack of proline catabolism due to a deficiency of intestinal proline oxidase impairs immune function in the gut (Ha et al. 2005).”
Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease (2017, background): “On the other, oxidant species, such as superoxide and hydrogen peroxide, can function as signaling molecules in a broad array of essential redox-dependent signaling pathways that are critical for the organismal survival including epidermal growth factor receptor signaling [202], inactivation of the ”
Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. (2009, background): “S1D), correlating with damage attributed to the proliferation of Ecc15 in the guts of Duox-deficient flies (Ha et al. 2005a).”
The gut microbiota of insects - diversity in structure and function. (2013, background): “Therefore, D. melanogaster eliminates excessive ROS by activating immune responsive catalases (Ha et al., 2005b).”
Functional amino acids and fatty acids for enhancing production performance of sows and piglets (2006, background): “Arbuckle and Innis (1993) Fish oil Increase in EPA and DHA concentrations in milk but ArA content was not affected.”
The host defense of Drosophila melanogaster. (2007, background): “Silencing of IRC by RNAi results in higher ROS production and fly lethality, indicating that IRC provides an antioxidant defense system in Drosophila (157).”
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. (2007, background): “A role for Duox in insect innate immunity has been proposed based upon the finding that when Duox expression is reduced in Drosophila intestine using RNAi, there is increased lethality upon exposure to food-borne bacteria [26].”
Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling (2018, neutral): “Furthermore, evidence is presented that burst production of ROS such as O2•− and/or H2O2 is an important component of the pathogen defense mechanism (Cross and Segal, 2004; Ha et al., 2005; Chávez et al., 2007).”