The long and the short of long–term memory—a molecular framework

By P. Goelet, V. Castellucci, S. Schacher, E. Kandel. 1986

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Citations in the corpus

Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. (2006, unknown): “Enduring forms of LTP and memory are dependent on mRNA and protein synthesis and rely on rearrangements in the structure and molecular composition of protein networks at synapses (Goelet et al., 1986; Sheng and Kim, 2002; Pocklington et al., 2006).”
Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning. (2001, background): “…et al. 2000; Schafe et al. 2000), consistent with the widely held belief that macromolecular synthesis is essential for the conversion of short to long-term memory in neurons that store associative memories (Davis and Squire 1984; Goelet et al. 1986; Dudai 1989; Bailey et al. 1996; Kandel 1997).”
Normally occurring environmental and behavioral influences on gene activity: from central dogma to probabilistic epigenesis. (1998, background): “Psychologists may be particularly interested in the fact that environmentally provoked gene expression is thought to be required for long-term memory (review in Goelet, Castellucci, Schacher, & Kandel, 1986 ).”
iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. (2014, unknown): “Application to Neuronal Activity Recent neuronal activity can be probed postmortem by the neuronal expression of immediate early genes (IEGs) (Goelet et al., 1986).”
Structural plasticity and memory (2004, background): “The idea that the creation of stable, persistent LTM traces requires gene expression and the resultant synthesis of new proteins is supported by much evidenc”
Making memories last: the synaptic tagging and capture hypothesis (2010, background): “What determines whether we remember or not? A longstanding theory is that the physical substrate of ' engrams ' or 'traces' for long-term memory (LTM) is an alteration in the efficacy of synapses within relevant neural network”
Synaptic plasticity and memory: an evaluation of the hypothesis. (2000, background): “Variable Persistence and Synaptic Tagging The temporal persistence of LTP has been linked to the intensity of NMDA receptor activation (Malenka 1991) and to the necessity for protein synthesis (Krug et al 1984, Goelet et al 1986).”
Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas (2006, background): “…the synthesis and synaptic capture of plasticity proteins that stabilize memory traces within neurons at the level of the individual synapse (Goelet et al., 1986; Frey & Morris, 1998b); and (ii) systems-level consolidation mechanisms which reflect a dynamic interaction between populations…”
Is Heterosynaptic modulation essential for stabilizing hebbian plasiticity and memory (2000, background): “It was found that memory in invertebrates has phase”
Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory. (2003, background): “…work in Drosophila (Belvin & Yin 1997), Aplysia (Montarolo et al. 1986), early learning in birds (Rose 1995), mammalian memory (Davis & Squire 1984), neural models of memory formation such as LTP (Krug et al. 1984) and theories about the relationship between STM and LTM (Goelet et al. 1986).”
Plasticity in the human central nervous system. (2006, background): “These molecules, in turn, initiate LTP expression mechanisms, either locally, where they phosphorylate receptors and alter the intrinsic properties of their ligand-gated ion channels, or by signalling to the cell nucleus via transcription factors to alter gene expression (Goelet et al., 1986; Alberi”
Transcription Factors in Long-Term Memory and Synaptic Plasticity (2009, unknown): “Together, these findings show that a cascade of gene expression in which transcription factors regulate the expression of other transcription factors, which in turn regulate the expression of effector genes, is an essential molecular signature for long-term memory formation (9, 77).”
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval (2000, background): “Much evidence indicates that this consolidation involves the synthesis of new proteins in neuron”