Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval

By Karim Nader, G. Schafe, J. L. Doux. 2000

2,498 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Social Psychology

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Citations in the corpus

Continual Relation Learning via Episodic Memory Activation and Reconsolidation (2020, background): “Yet later work (Nader et al., 2000; Lee et al., 2004; Alberini, 2005) in neuroscience indicates that reactivation of consolidated memory triggers a reconsolidation stage to continually maintain memory, and memory is easy to be changed or erased in this stage.”
Emotional Processing Theory (EPT) and Exposure Therapy for PTSD (2006, result): “Consistent with these results is the finding in animal research that the amygdala must be activated in order for extinction to occur ( Nader, Schafe, & LeDoux, 2000 ).”
Commentary — reconsolidation: Strengthening the shaky trace through retrieval (2000, background): “Embedded in this literature, however, there were several papers showing that temporally graded retrograde amnesia could be obtained for a well-established memory when the trace was reactivated just before the amnesic treatment (for a review, see ref”
Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning. (2001, background): “…synthesis in LA and surrounding areas prevents the consolidation of long-term memory for associative auditory fear conditioning (Bailey et al. 1999; Nader et al. 2000; Schafe et al. 2000), consistent with the widely held belief that macromolecular synthesis is essential for the conversion of short…”
Memory processes in classical conditioning. (2004, background): “[104] who found that introduction of anisomycin likewise abolished a reactivated memory (see also [105] for a related effect of MK-801).”
Preventing the return of fear in humans using reconsolidation update mechanisms (2009, background): “…the lateral amygdala induced by the conditioned stimulus retrieval was impaired by the presentation of a conditioned stimulus 1 h later, indicating possible interference with the reconsolidation process, similar to the interference caused to reconsolidation by pharmacological blockade in rats 4 .”
The medial temporal lobe. (2004, background): “The second topic is the concept of what has been newly termed reconsolidation (Nader et al. 2000), which revives older claims (Misanin et al. 1968) that reactivation of a consolidated memory can sometimes make information vulnerable to interference or disruption.”
Cellular and systems reconsolidation in the hippocampus. (2002, neutral): “(Nader et al., 2000a).”