Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity.

By P. Shaw, S. Hörkkö, Mi-Kyung Chang, L. Curtiss, W. Palinski, G. Silverman, J. L. Witztum. Journal of Clinical Investigation, 2000

716 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/ca29562b39be6ae32822a023d36da0db72d3b99d

How researchers see this paper

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In Immunology

1. Peter Libby
2. G. Hansson
3. Christopher K. Glass
4. J. Savill
5. N. Baumgarth
6. I. Tabas
7. P. Calder
8. P. Ridker

In Molecular Biology

1. Peter Libby
2. G. Hansson
3. Christopher K. Glass
4. J. Savill
5. P. Ridker

In Surgery

1. G. Hansson
2. Peter Libby
3. Christopher K. Glass
4. I. Tabas
5. P. Calder
6. A. Lichtman
7. K. Moore

Citations in the corpus

• The immune response in atherosclerosis: a double-edged sword (2006, background): “; whereas oxLDL-specific antibodies react with oxidized phospholipids such as phosphorylcholin”
• Antiinflammatory Properties of HDL (2004, background): “The epitope recognized by the EO6 antibody is shared by “natural” T15 anti-phospholipid antibodies that are protective against Streptoccous pneumoniae [27].”
• A blast from the past: clearance of apoptotic cells regulates immune responses (2002, background): “; some overlap with the innate recognition of non-self is emphasized by the capacity of naturally occurring antibodies specific for oxidised lipids to modulate the uptake of oxLDL and apoptotic cells by macrophages, in addition to protecting against pneumococcal infectio”
• Atherosclerosis The Road Ahead (2001, background): “Lesions provide optimal protection to mice against lethal infecwere less cellular and had decreased collagen content. tion with S. pneumoniae (Shaw et al., 2000).”
• The Impact of Oxidative Stress and Inflammation on RPE Degeneration in Non-neovascular AMD (2017, background): “One OxPL species is the oxidation of the phosphocholine (PC) moiety of phospholipids, which are detected and bound by the IgM natural antibody E06, but not to the PC moiety of unoxidized phospholipids (Friedman et al., 2002; Shaw et al., 2000).”
• The double life of a B-1 cell: self-reactivity selects for protective effector functions (2011, background): “Binding of natural IgM to oxidized low-density lipoproteins can also decrease the development of atherosclerosi”