NOD-like receptors: role in innate immunity and inflammatory disease.

By Grace Y. Chen, Michael H. Shaw, Yun-Gi Kim, G. Núñez. Annual Review of Pathology, 2009

794 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ca02889be54ec7fcd28aa06a20d1b77eec695a7c

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In Emergency Medical Services

J. Tschopp

In Immunology

In Molecular Biology

Citations in the corpus

Thioredoxin-interacting protein links oxidative stress to inflammasome activation (2010, background): “1831" language="eng" relation="no"> Active, mature interleukin 1β (IL-1β) is produced by cleavage of the inactive pro-IL-1β precursor by caspase-1, which is activated in a large multiprotein complex called the inflammasom”
Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders (2017, background): “First, IL-1β production is not the only biological effect of NLRP3 inflammasome activation; the pyroptosis or other proinflammatory factors, such as IL-18 and HMGB1, might also are involved in the pathogenesis of diseases (Lu et al., 2012; Nowarski et al., 2015).”
Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “The interferon response to intracellular DNA: why so many receptors? Immunobiology 218(11):1312–21 227.”
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “Once activated, the NLRP3 inflammasome initiates the inflammatory response cascade by stimulating caspase-1 (casp-1) that acts to induce the active precursors of pro-inflammatory cytokines, such as IL-1β, IL-1α, and IL-18, and on-going interaction with NF-κB (130, 131) (Figure 4).”
Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding (2016, neutral): “y = A0(1)e−k t 1 + A0(2)e−k t 2 + offset (4)”
An evolving arsenal: viral RNA detection by RIG-I-like receptors (2014, background): “In mammalian cells, pattern recognition receptors (PRRs) protect against host infection by recognizing specific pathogen associated molecular patterns (PAMPs) and eliciting signals that initiate an immune response [1] [2] [3] [4] .”