An evolving arsenal: viral RNA detection by RIG-I-like receptors

By Megan E. Fitzgerald, David C. Rawling, Adriana Vela, Anna Marie Pyle. 2014

41 citations recorded by the source corpus.

Highlights • RIG-I-like receptors (RLRs) have similar architectures but unique recognition domains.• Structural diversity among RLRs provides multiple strategies for detecting viral RNA.• Viruses evade detection by exploiting RLR specificity for RNA determinants.• RLR architecture has evolved in response to variations in viral RNA diversity.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Immunology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Wenshuai Wang
2. Anna Marie Pyle

In Epidemiology

1. Wenshuai Wang
2. Anna Marie Pyle

In Immunology

1. Wenshuai Wang
2. Anna Marie Pyle

Citations in the corpus

• The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands (2022, positive): “This multidomain protein is essential for effective host response to the most significant viral health threats impacting society today, including coronaviruses, influenza, flaviviruses, andmany more (Chen et al., 2016; Chiale et al., 2022; Diamond and Kanneganti, 2022; Fitzgerald et al., 2014;Madden”