High Impulsivity Predicts the Switch to Compulsive Cocaine Taking

By D. Belin, A. Mar, J. Dalley, Trevor W. Robbins, Barry J. Everitt. Science, 2008

1,002 citations recorded by the source corpus.

Both impulsivity and novelty-seeking have been suggested to be behavioral markers of the propensity to take addictive drugs. However, their relevance for the vulnerability to compulsively seek and take drugs, which is a hallmark feature of addiction, is unknown. We report here that, whereas high reactivity to novelty predicts the propensity to initiate cocaine self-administration, high impulsivity predicts the development of addiction-like behavior in rats, including persistent or compulsive drug-taking in the face of aversive outcomes. This study shows experimental evidence that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Social Psychology

View Paper: https://www.semanticscholar.org/paper/c9faf1d685c381b7d4b662594e4ec73455a86709

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Citations in the corpus

Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction (2008, background): “However, and in marked contrast, it was high impulsivity, but not high reactivity to novelty, that predicted the switch (Leshner 1997) from controlled to compulsive cocaine taking (Belin et al. 2008).”
Reward Processing by the Opioid System in the Brain (2009, positive): “Finally, multidimensional models take into account several hallmarks of addiction to predict the development of addictive-like behavior in rats (33, 34, 100).”
The role of impulsive behavior in drug abuse (2008, methodology): “In addition, a recent report indicated that HiI rats were more likely to progress from initiation of drug taking to compulsive drug-seeking behavior, measured by animal models of three DSM-IV criteria (Belin et al. 2008).”
Understanding how and why psychotherapy leads to change (2009, background): “Indeed, basic biological research (eg, animal models of addiction) suggests antecedents (eg, impulsivity as a vulnerability to addiction) that might well prove to be targets for psychotherapeutic intervention (see Belin, Mar, Dalley, Robbins, & Everitt, 2008 ).”
Impulsivity, compulsivity, and top-down cognitive control. (2011, neutral): “By contrast, choice of the delayed option was associated with higher activity in the lateral PFC and orbitofrontal cortex (Hariri et al., 2006; McClure et al., 2007), suggesting some form of balance between these systems, support for which has been noted in recent rodent studies (Mar et al., 2008).”
Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review (2010, background): “…in a spiraling manner (Brewer and Potenza, 2008) reminiscent of elaborately spiraling striato-nigrostriatal circuitry identified in primate (Lynd-Balta and Haber, 1994) and rodent (Belin et al, 2008) models of motivated behaviors mapping transitional processes from dorsal to ventral striatum.”
Reward Mechanisms in Obesity: New Insights and Future Directions (2011, background): “Indeed, rats with a history of extensive cocaine consumption display intake that is resistant to disruption by an aversive conditioned stimulus (CS) predicting negative outcome (i.e., a cue light that predicts delivery of aversive footshock) (Belin et al., 2008; Vanderschuren and Everitt, 2004).”