Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review

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Risk assessment as an evolved threat detection and analysis process. (2011, background): “All of these have some involvement with motor functioning, and the striatum has been linked to OCD (Fineberg et al., 2010), consonant with a view that they may be particularly associated with specific behavioral aspects of defense.”
Pro v Con Reviews: Is Food Addictive? (2012, background): “Given that dysfunction in OFC and ACC results in compulsivity (see review (85)), this might be part of the mechanism by which low-striatal D2R signalling facilitates hyperphagia (86,87).”
Reward Mechanisms in Obesity: New Insights and Future Directions (2011, background): “…(i.e., prefrontal cortex) and in interoceptive processing (insular cortex) have been heavily implicated in drug addiction (Everitt et al., 2008; Fineberg et al., 2010; Koob and Volkow, 2010; Naqvi and Bechara, 2009), yet little is known of their precise role in compulsive eating and obesity,…”
Introduction to Behavioral Addictions (2010, background): “In particular, serotonin (5-HT), which is involved with inhibition of behavior, and dopamine, involved with learning, motivation, and the salience of stimuli, including rewards, may contribute significantly to both sets of disorders (42, 43).”