Intracellular signalling: Key enzyme in leptin-induced anorexia

By K. Niswender, G. Morton, Walter H. Stearns, C. Rhodes, M. G. Myers, M. Schwartz. Nature, 2001

609 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/c9e057b410b2ebff09ff9251ae20d8fdc411d324

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. M. Myers
2. P. Havel
3. J. Flier
4. G. Frühbeck
5. Barry M. Popkin
6. P. Trayhurn

In Nutrition and Dietetics

1. M. Myers
2. P. Havel
3. J. Flier
4. G. Frühbeck

In Physiology

1. M. Qatanani
2. P. Havel
3. C. Mantzoros
4. J. Flier
5. Mitchell A. Lazar
6. G. Frühbeck
7. Barry M. Popkin
8. P. Trayhurn

Citations in the corpus

• Mechanisms of leptin action and leptin resistance. (2008, background): “These signals may include the LRb Tyr1077/STAT5 pathway or signals mediated by the LRb-associated Jak2 independently of LRb tyrosine phosphorylation (3, 60, 74).”
• Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “…processes information from adiposity signals such as insulin and leptin, which circulate in proportion to body fat mass, and integrates this input with signals from nutrients such as FAs (Burcelin et al. 1999; Niswender et al. 2001; Obici et al. 2003; Seeley and Woods 2003; Pocai et al. 2006).”
• Intracellular signalling pathways activated by leptin. (2006, background): “Leptin has been shown to stimulate IRS2-mediated hypothalamic PI3K activity, while pharmacological blockade of PI3K abrogated the leptin-induced hyperpolarization of NPY/AgRP (agouti-related peptide) neurons, thus blocking the anorectic effect of leptin [58,135].”
• Leptin regulation of the mesoaccumbens dopamine pathway. (2006, positive): “Leptin exerts its actions on energy balance through the long-form of the leptin receptor (ObRb), via signals including the JAK-STAT3 and PI-3 kinase pathways (Tartaglia et al., 1995; Baumann et al., 1996; Vaisse et al., 1996; Niswender et al., 2001; Zhao et al., 2002).”
• Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. (2005, background): “The actions of insulin and leptin to reduce food intake share a common signaling pathway via activation of PI-3-kinase.(154) Defects in the ability to produce leptin(155) or the leptin receptor(156) lead to marked hyperphagia and morbid obesity in humans.”
• Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications (2010, background): “The binding of leptin to the ObRb receptor activates several signal transduction pathways, including Janus kinase signal transducer and activator of transcription 3 (JAK-STAT3), which is important for regulation of energy homeostasis (15), and phosphatidylinositol 3-kinase (PI3K), which is important”