Alveolar macrophages: plasticity in a tissue-specific context

By T. Hussell, T. Bell. Nature reviews. Immunology, 2014

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Progress in tumor-associated macrophage (TAM)-targeted therapeutics (2017, neutral): “Specific macrophage subsets in protective barriers, such as the Langerhans cells in the skin [14] and the alveolar macrophages within the lung [15], are responsible for both clearing pathogenic material and raising local inflammatory responses.”
Macrophage Polarization in Inflammatory Diseases (2014, background): “For instance, Kupffer cells (KCs) limit the severity of the virally infected liver through removing apoptotic hepatocytes in a manner dependent on scavenger receptors and thus play a major pathological role in chronic virus associated diseases [31]; alveolar macrophage is not only the monitor of cle”
Macrophage heterogeneity in tissues: phenotypic diversity and functions (2014, background): “The group of Tracey Hussell (98) has studied acute coinfection by viral and Gram-positive bacterial pathogens via the airway, as well as the resolution of pathologic lesions after inflammation.”
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment (2014, background): “Enhancers unique to lung macrophages were enriched for genes involved in metabolism of lipids and lipoproteins, indicating the role of these cells in surfactant lipoprotein metabolism (Hussell and Bell, 2014) (Table S3, cluster VIII).”