Macrophages are required for adult salamander limb regeneration

By J. Godwin, Alexander R. Pinto, Nadia A. Rosenthal. Proceedings of the National Academy of Sciences of the United States of America, 2013

797 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Cellular Senescence: Aging, Cancer, and Injury. (2019, result): “It is likely that macrophage-mediated clearance is required for tissue remodeling, similar to observations in developing embryos (235, 305), as depleting macrophages in salamander leads to regenerative defects (140).”
Wound Healing: A Cellular Perspective. (2019, background): “Fascinatingly, replenishment of endogenous macrophages following amputation in these macrophage-depleted salamanders restores limb regeneration (146).”
Origin and Functions of Tissue Macrophages (2014, background): “Model organisms, including salamanders, zebrafish, and neonatal mice, all require macrophages for tissue regeneration; however, no studies have addressed the contribution of distinct macrophage subtypes and/or lineages in this process (Godwin et al., 2013; Aurora et al., 2014; Huang et al., 2013).”
Wound repair and regeneration: Mechanisms, signaling, and translation (2014, positive): “…a tail) coincides with a spike in immune cell presence (133); yet, recent studies in both adult salamander limb and zebrafish fin regeneration indicate that an innate immune cell influx, particularly of macrophages, preceding blastema formation is an essential component of regeneration (134, 135).”