Genetics of myeloid leukemias.

By Louise M. Kelly, D. Gilliland. Annual review of genomics and human genetics (Print), 2003

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The impact of translocations and gene fusions on cancer causation (2007, background): “Finally, there is circumstantial and direct evidence from murine leukaemia models that additional events are a prerequisite for malignant transformatio”
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma (2007, methodology): “In particular, chromosomal translocations resulting in production of constitutively active kinase fusion protein products are implicated as causative factors of selected leukemias and other human cancers (3, 4).”
Applying the principles of stem-cell biology to cancer (2003, background): “Indeed, several groups have shown that leukaemogenic mutations increase the proliferation and block the differentiation of normal haematopoietic stem/progenitor cell”
Cancer stem cells: an old idea--a paradigm shift. (2006, background): “induce transformation of myeloid progenitor cells enabling them to acquire the property of self-renewal (25).”