Microglial Interactions with Synapses Are Modulated by Visual Experience

By Marie-Eve Tremblay, Rebecca Lowery, Ania Majewska. PLoS Biology, 2010

1,417 citations recorded by the source corpus.

Microglia, the brain's immune cells, show unique interactions with nearby synaptic elements under non-pathological conditions that are sensitive to changes in sensory experience.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/c8cdc029730a496d3cdd51284a4ce917b147388f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Pekny
2. M. Sofroniew
3. M. Pekna
4. E. Hol
5. Guang Yang
6. Alexei Verkhratsky
7. B. Barres
8. Beth Stevens

In Neurology

1. M. Sofroniew
2. R. Ransohoff
3. M. Pekny
4. B. Barres
5. M. Pekna
6. Alexei Verkhratsky
7. E. Hol
8. Beth Stevens

Citations in the corpus

• Depression as a microglial disease. (2015, background): “The microglial–neuronal interactions depend on neuronal activity, particularly in specific environmental contexts such as sensory stimulation/deprivation and specific learning and memory tasks [176,177].”
• Microglial M1/M2 polarization and metabolic states (2016, background): “Similar to macrophages, microglia mount an immune response to pathogens, monitor for tissue changes and maintain tissue homeostasis by clearing pathogens, dying cells, debris or aberrant proteins (Gehrmann et al., 1995; Bruce-Keller, 1999; Stevens et al., 2007; Wake et al., 2009; Nagamoto-Combs et a”
• Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain (2017, background): “…invasive methods have revealed microglia to be highly dynamic in their interaction with the microenvironment, responding to inflammatory signals (Nimmerjahn et al., 2005; Davalos et al., 2005) and interacting with neuronal circuits at the synaptic level (Tremblay et al., 2010;Wake et al., 2009).”
• Origin and differentiation of microglia (2013, background): “In the steady state, microglial cells constantly survey their local microenvironment, extending their motile processes to make transient contact with neuronal synapses, contributing to the modification and the elimination of synaptic structures (Tremblay et al., 2010).”
• Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness (2016, background): “2011) and plasticity in the healthy brain (Parkhurst et al. 2013; Tremblay et al. 2010) and are able to rapidly respond to even minor changes in the brain (Lawson et al.”
• Microglia: Dynamic Mediators of Synapse Development and Plasticity (2015, background): “Furthermore, decreasing the strength of synaptic input to the visual cortex during dark adaptation causes decreased microglia process motility that was reversed upon re-exposure to light and visual stimulation [22].”
• Astrocytes: a central element in neurological diseases (2016, background): “The synaptic assembly also includes a microglial cell process that frequently senses the synapse status [114, 229, 242].”