Microglia: Dynamic Mediators of Synapse Development and Plasticity
By Yuwen Wu, Lasse Dissing‐Olesen, B. MacVicar, Beth Stevens. Trends in immunology, 2015
594 citations recorded by the source corpus.
Neuronal communication underlies all brain activity and the genesis of complex behavior. Emerging research has revealed an unexpected role for immune molecules in the development and plasticity of neuronal synapses. Moreover microglia, the resident immune cells of the brain, express and secrete immune-related signaling molecules that alter synaptic transmission and plasticity in the absence of inflammation. When inflammation does occur, microglia modify synaptic connections and synaptic plasticity required for learning and memory. Here we review recent findings demonstrating how the dynamic interactions between neurons and microglia shape the circuitry of the nervous system in the healthy brain and how altered neuron-microglia signaling could contribute to disease.
Subfields: Cellular and Molecular Neuroscience, Immunology, Neurology
View Paper: https://www.semanticscholar.org/paper/083e4f4cdb0490ba2d2cd6301e68b9629a854dc8
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Immunology
Citations in the corpus
- Microglia in Alzheimer’s disease (2018, background): “…of complement activation, is also reported to provide neuroprotection (Shi et al., 2015, 2017a; Hong et al., 2016; for different results, see Wyss-Coray et al., 2002; Maier et al., 2008), though it appears to increase amyloid burden (Wyss-Coray et al., 2002; Maier et al., 2008; Shi et al., 2017a).”