Facile detection of mitochondrial DNA mutations in tumors and bodily fluids.

By Makiko Fliss, H. Usadel, O. Caballero, Li Wu, Martin R Buta, S. Eleff, J. Jen, D. Sidransky. Science, 2000

838 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c8bc1681b201ffe11f96c873c5defcdcd5b616bd

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In Molecular Biology

Citations in the corpus

Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. (2009, background): “Mutations and altered expression in mitochondrial genes encoding for complexes III, IV, V, and I and in the hypervariable regions of mitochondrial DNA have been identified in various human cancers [68-70].”
Mitochondrial defects in cancer (2002, background): “There are a limited number of reports regarding mtDNA mutations in solid tumors of the bladder, head and neck, and lung [68,69].”
Genomic alterations in cultured human embryonic stem cells (2005, background): “Mitochondrial DNA mutations are commonly observed in most human cancer”
Mitochondrial mutations in cancer (2006, background): “For the 16S rRNA gene, the nt 1811 A to G variant (Fliss et al., 2000) subdivides haplogroup U (Montiel-Sosa et al., 2005).”
Organelle-specific initiation of cell death pathways (2001, background): “However, mtDNA mutations and deletions are frequently found in cancer cell”
Predicting lung cancer by detecting aberrant promoter methylation in sputum. (2000, background): “One of the latest markers proposed for noninvasive detection of cancer is mitochondrial DNA mutation (19).”
Mitochondrial DNA (2009, neutral): “Time-lapse imaging has shown that nucleoids in mammalian cells are relatively stable structures rather evenly spaced within the mitochondrial reticulum (6, 7).”
Emerging molecular markers of cancer (2002, background): “This work was quickly expanded to identify mitochondrial mutations in more than 50% of tumour types, including lung, head and neck, bladder and breast cancer”
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine (2005, background): “Subsequently, a variety of mtDNA-coding region and CR mutations have been reported in colon cancer cells (4,66,181), head and neck tumors (58), astrocytic tumors (95), thyroid tumors (129,253), breast tumors (209), and prostate tumors (33,34,38,177).”