Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

By R. Anson, Zhihong Guo, R. de Cabo, Titilola Iyun, M. Rios, Adrienne Hagepanos, D. Ingram, M. Lane, Mark P. Mattson. Proceedings of the National Academy of Sciences of the United States of America, 2003

745 citations recorded by the source corpus.

Subfields: Aging, Physiology

View Paper: https://www.semanticscholar.org/paper/c7b41e3f27cc4859e4f5628adc08cdaff83d3020

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Citations in the corpus

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity (2012, background): “Improved glucose tolerance and insulin sensitivity are hallmarks of CR in mammals, and a common feature of many models of increased longevity (12-16), although mice lacking insulin receptor substrate (IRS) proteins 1 or 2 provide a notable counterexample (17, 18).”
Caloric restriction. (2011, background): “Surprisingly, despite this rather small deficit in energy intake relative to control levels, these IF animals experience the same enhanced longevity found with CR (Goodrick et al., 1990; Anson et al., 2003).”
Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. (2007, background): “Similar to daily CR (on a long-term basis), intermittent CR can extend lifespan and protect multiple organ systems against disease in rodents [22] [23] [24].”
Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. (2018, positive): “Indeed, data in rodents suggest that IF improves cardiometabolic endpoints even when food intake and/or body weight is matched to the control group (Anson et al., 2003; Belkacemi et al., 2012; Hatori et al., 2012; Olsen et al., 2017; Sherman et al., 2012; Woodie et al., 2017; Wu et al., 2011; Zarrin”
Spermidine in health and disease (2018, background): “However, it is difficult to set the optimal intensity of CR to avoid undernourishment and other unwanted effects, for which reasons CR is contraindicated in elderly and diseased persons (1, 4, 5).”
Fasting: Molecular Mechanisms and Clinical Applications (2014, background): “…regular aerobic exercise, including increased insulin sensitivity and cellular stress resistance, reduced resting blood pressure and heart rate, and increased heart rate variability as a result of increased parasympathetic tone (Figure 2) (Anson et al., 2003; Mager et al., 2006; Wan et al., 2003).”
Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males (2016, background): “These reported effects are probably mediated through changes in metabolic pathways and cellular processes such as stress resistance [24], lipolysis [3, 17, 25–27], and autophagy [28, 29].”
Flipping the Metabolic Switch: Understanding and Applying Health Benefits of Fasting (2017, background): “Interestingly, levels of insulin-like growth factor 1 (IGF-1) are reduced at the end of the 3-day fasting period in mice on the 4:3 diet (66), whereas IGF-1 was not reduced, and even increased, in mice on the ADF diet (60).”
Calorie restriction, SIRT1 and metabolism: understanding longevity (2005, background): “After maintenance on an every-other-day feeding schedule with no reduction in overall calories (with maintained vitamin and mineral intake), intermittently fed mice showed similar metabolic changes to mice that were kept on a calorie-restricted diet, including a decrease in body temperature, decreas”
Impact of intermittent fasting on health and disease processes (2016, positive): “…those of mice fed ad libitum but, nevertheless, exhibit highly significant improvements in glucose metabolism (reduced glucose and insulin levels) and mobilization of fatty acids (increased -hydroxybutyrate levels) that were as great or even greater than mice on a 40% CR diet (Anson et al., 2003).”