Control of Human Telomere Length by TRF1 and TRF2

By A. Smogorzewska, B. van Steensel, A. Bianchi, S. Oelmann, M. Schaefer, G. Schnapp, T. de Lange. Molecular and Cellular Biology, 2000

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Subfields: Physiology

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Telomere length, stem cells and aging. (2007, background): “TRF1 and the TRF1-interacting proteins have been proposed to regulate telomere length by controlling the access of telomerase to the telomer”
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion (2005, background): “Because TRF1 binds TTAGGG repeats at chromosome internal sites as well as at telomere”
Identification of human Rap1: implications for telomere evolution. (2000, neutral): “Each of these four proteins binds to the C termipressing cells (van Steensel and de Lange, 1997; Kim nus of Rap1p, and tethering of this domain to telomeres et al., 1999; Smogorzewska et al., 2000); overexpression in themselves can result in resetting of telomere length of full-length TRF1 and TRF2 ”
How shelterin protects mammalian telomeres. (2008, background): “Similarly, TIN2, TPP1, and POT1 behave as negative regulators of telomerase-mediated telomere elongation (84, 99, 120, 176, 204).”
Human Telomerase and Its Regulation (2002, background): “Overexpressed TRF2 causes telomere shortening in both telomerase-positive and -negative cells (118, 216).”