How shelterin protects mammalian telomeres.
By Wilhelm Palm, T. de Lange. Annual Review of Genetics, 2008
1,856 citations recorded by the source corpus.
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/19bd5f48cebe71a33076be8abe8cb2aa8178dc17
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- J. Karlseder
- T. de Lange
- D. Hockemeyer
- Agnel Sfeir
- Roderick J. O’Sullivan
- Sheila L. MacRae
- C. Schildkraut
- Settapong T. Kosiyatrakul
In Physiology
- T. de Lange
- J. Karlseder
- D. Hockemeyer
- Roderick J. O’Sullivan
- Agnel Sfeir
- Sheila L. MacRae
- C. Schildkraut
- Settapong T. Kosiyatrakul
Citations in the corpus
- The MRE11 complex: starting from the ends (2011, background): “This protein assembly, called shelterin in mammals, together with the unique DNA sequences at chromosome ends, defines the telomer”
- Advance Publication by J-STAGE Japanese Journal of Infectious Diseases Isolation of human coronaviruses OC43, HKU1, NL63, and 229E in Yamagata, Japan, using primary human airway epithelium cells cultured by employing an air-liquid interface culture (2020, neutral): “TRF2 is structurally similar to TRF1, except that its N-terminal end contains more basic amino acid residues [30].”
- Telomeres: protecting chromosomes against genome instability (2010, background): “In mammals this complex is termed shelterin and consists of six individual proteins: telomeric repeat-binding factor 1 ( TRF1 ; also known as TERF1), TRF2 (also known as TERF2), repressor and activator protein 1 ( RAP1 ; also known as TERF2IP), TRF1-interacting nuclear protein 2 ( TIN2 ; also know”
- Oxidative Stress, Mitochondrial Dysfunction, and Aging (2011, neutral): “that protects the integrity of telomeres [88].”
- Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication (2009, positive): “Although TRF1 has a similar architecture as TRF2 (Fairall et al., 2001), it has distinct domains and a different set of interacting partners (Chen et al., 2008; reviewed in Palm and de Lange, 2008).”
- Alternative lengthening of telomeres: models, mechanisms and implications (2010, background): “This nucleoprotein complex prevents the chromosome end from being detected as a DNA double-strand break (DSB”
- Mitochondrial Energetics and Therapeutics (2010, neutral): “They also activate p53 to induce p21, inhibit Cdk, and block the cell cycle (218).”