The Role of the Transcription Factor CREB in Immune Function

By An Wen, K. Sakamoto, L. Miller. Journal of Immunology, 2010

792 citations recorded by the source corpus.

CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element. Several immune-related genes possess this cAMP-responsive element, including IL-2, IL-6, IL-10, and TNF-α. In addition, phosphorylated CREB has been proposed to directly inhibit NF-κB activation by blocking the binding of CREB binding protein to the NF-κB complex, thereby limiting proinflammatory responses. CREB also induces an antiapoptotic survival signal in monocytes and macrophages. In T and B cells, CREB activation promotes proliferation and survival and differentially regulates Th1, Th2, and Th17 responses. Finally, CREB activation is required for the generation and maintenance of regulatory T cells. This review summarizes current advances involving CREB in immune function—a role that is continually being defined.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/1f9165561830c8612e5d59e5e24afca460030a35

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In Cancer Research

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In Immunology

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Citations in the corpus

• Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “…but is also consistent with a model of transcriptional competition between NF-kB and the cAMP-activated transcription factor cAMP response element binding protein (CREB) (Guo et al., 2015; Kawamata et al., 2003; Keitel et al., 2008; Pols et al., 2011; Wang et al., 2011a; Wen et al., 2010).”
• Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation (2014, methodology): “…programs such as those described in Figure 3 can be found in human tissue macrophages, we compiled two data sets of human alveolar macrophages obtained by bronchoalveolar lavage (Shaykhiev et al., 2009; Woodruff et al., 2005) consisting of samples from nonsmokers, smokers, and COPD patients.”