PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

By C. Day, D. Kaufmann, P. Kiepiela, Julia A. Brown, Eshia S. Moodley, S. Reddy, Elizabeth W. Mackey, Joseph D. Miller, A. Leslie, Chantal DePierres and 12 more. Nature, 2006

2,853 citations recorded by the source corpus.

Subfields: Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/c67505e59cfb669ebd6682873a89fea7888836d3

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In Immunology

1. E. Wherry
2. Arlene H. Sharpe
3. G. Freeman
4. Ton N. Schumacher
5. S. Rosenberg
6. D. Thommen
7. B. Fife
8. V. Kuchroo

In Virology

1. Daniel C. Douek
2. Mario Roederer
3. R. Koup
4. V. Appay
5. D. Sauce

Citations in the corpus

• Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients (2010, background): “Using HLA-A2 tetramers, NY-ESO-1–, CMV-, EBV-, and Flu-specific CD8+ T cells present in PBMCs of and humans (Barber et al., 2006; Day et al., 2006; Petrovas et al., 2006; Trautmann et al., 2006).”
• The PD-1 Pathway in Tolerance and Autoimmunity (2010, positive): “Together with reports correlating PD-1 as a marker for T-cell exhaustion during viral infection (10, 193), these data suggest that some exhausted CD4PD-1 T cells may become iTregs upon stimulation through the PD-L1: PD-1 pathway, thus representing another means of de novo iTreg conversion.”
• Emerging Concepts in the Immunopathogenesis of AIDS (2009, background): “Whereas some studies have linked expression of PD-1 on CTLs to impaired production of cytokines (91, 92, 94), others have emphasized the predominant role of this receptor in regulating the survival of these cells (93, 96–99).”
• Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production (2013, background): “…differences in JEM Vol. 210, No. 1 Article 151 Because PD-1, which was coexpressed with Ki-67, may define cells with reduced proliferation capacity (Day et al., 2006; Trautmann et al., 2006), the four sorted purified memory CD4 T cell populations were stimulated with anti-CD3 plus anti-CD28…”
• Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations (2018, background): “Originally described in the context of chronic viral infections, where the host fails to clear the pathogen, it is now apparent that exhausted T cells can also occur in cancer (12, 13).”
• Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging (2018, background): “Expression of IRs is often associated with diminished functional capacity, frequently called immune exhaustion, in HIV, aging and other chronic diseases (50, 53, 59).”
• Germinal-center organization and cellular dynamics. (2007, background): “PD-1 is upregulated on chronically stimulated T cells (Barber et al., 2006; Day et al., 2006), and it seems possible that the high level of PD-1 on GC T cells is an indication of chronic encounter with antigen-presenting GC B cells.”