Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia.

By Terry E. Goldberg, Michael Egan, Tonya Gscheidle, Richard Coppola, T. Weickert, Bhaskar S. Kolachana, D. Goldman, Daniel R. Weinberger. Archives of General Psychiatry, 2003

627 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/c63b8d5b5767e145d9a95e3ede31fab10d79dca0

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Citations in the corpus

Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. (2008, background): “The val166met polymorphism of the COMT gene is currently one of the more widely studied SNPs in relation to neurocognitive functioning, with the val genotype associated with higher enzyme activity and inferior working memory and behavioural flexibility in healthy subjects (Egan et al., 2001; Goldber”
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. (2004, background): “Indeed, clinical studies of COMT have revealed that the Met allele, which encodes the enzyme with lower activity, is associated with better performance on tests of prefrontally mediated cognition (Egan et al. 2001; Goldberg et al. 2003; Mattay et al. 2003; Diamond et al. 2004; Nolan et al. 2004).”
Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis (2006, background): “These include COMT (Goldberg et al., 2003), Dysbindin (Blake et al., 1998), Neuregulin (Falls, 2003), Regulator of G-protein Signaling 4 (RGS4; Williams et al., 2004), Disrupted In Schizophrenia 1 (DISC1; Cannon et al., 2005), metabotrophic glutamate receptor3 (GRM3; Egan et al., 2004) and G-72 (Chu”
The principal features and mechanisms of dopamine modulation in the prefrontal cortex. (2004, background): “In schizophrenia, there appears to be excessive transmission of the allele that produces more COMT activity and less PFC DA (Egan et al., 2001; Weinberger et al., 2001; Goldberg et al., 2003; Matsumoto et al., 2003).”
The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes (2004, background): “Goldberg et al (2003) noted that there was no interaction of genotype with ‘n’ across the 1-back and 2- back conditions, but this does not help disentangle maintenance from updating demands since these are confounded in the n-back task (ie as ‘n’ increases, so do demands for both maintenance of the…”
Individual differences in executive functions are almost entirely genetic in origin. (2008, background): “The genetic influences on executive functions have been of increasing interest to psychologists in a wide variety of domains (e.g., Diamond, Briand, Fossella, & Gehlbach, 2004; Goldberg et al., 2003; Nigg, Blaskey, Stawicki, & Sachek, 2004).”
Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives (2007, background): “particular the COMT Val(158)Met polymorphism and other polymorphisms on the same gene, that have been associated with prefrontal cognitive functioning in schizophrenia and bipolar patients and their firstdegree relatives (Goldberg et al. 2003 ; Rosa et al. 2004; Bertolino et al. 2006 ; Mata et al. 2”
Cognitive fitness of cost-efficient brain functional networks (2009, methodology): “As anticipated by extensive prior data on executive function deficits in schizophrenia (19, 20), the patients performed the working-memory task less accurately: Mean percentage of correct trials was 70.”