Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models

By E. Murphy, Paul D. Cotter, S. Healy, Tatiana M. Marques, O. O’Sullivan, F. Fouhy, Siobhan F Clarke, P. O’Toole, E. M. Quigley, Catherine Stanton and 3 more. Gut, 2010

930 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Gastroenterology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c547c91d3f08db21e9ce81573f32bdb73cb6e1bc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. Jeroen Raes

In Molecular Biology

1. Patrice D Cani
2. W. D. de Vos
3. Jesse Stombaugh
4. Rob Knight
5. Jeroen Raes
6. J. Rawls
7. Tong Zhang
8. Lin Ye

Citations in the corpus

• Next‐generation sequencing technologies for environmental DNA research (2012, background): “Also, several studies have been conducted on the effect of diet on the gut microbiome of mice using 16S rDNA amplicons (Turnbaugh et al. 2008, 2009; Murphy et al. 2010; Ravussin et al. 2011; Serino et al. 2011).”
• Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity (2012, result): “found an increased proportion of Firmicutes and a reduction in Bacteroidetes in similar dietary conditions.(42) More recently, Ravussin et al.”
• Diet and Feeding Pattern Affect the Diurnal Dynamics of the Gut Microbiome (2014, positive): “A high-fat diet (HFD) can increase Firmicutes in the gut microbiome without altering host metabolism, suggesting that many observed shifts in the microflora result from dietary changes and may not have metabolic consequences (Hildebrandt et al., 2009; Murphy et al., 2010).”
• How informative is the mouse for human gut microbiota research? (2015, background): “A reduced ratio of Firmicutes:Bacteroidetes was also found in a study linking gut microbiota composition and metabolic adaptations in mice on highfat diets (Serino et al., 2012).”
• Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish (2012, background): “, 2005), mice fed high-calorie Western diets (Turnbaugh et al., 2008; Hildebrandt et al., 2009; Murphy et al., 2010), and postprandial pythons (Costello et al.”
• Regulation of Inflammation by Short Chain Fatty Acids (2011, background): “Modifications in the concentrations or the ability of host tissues to use SCFAs have been described in these conditions [9–13].”
• Impact of the gut microbiota on inflammation, obesity, and metabolic disease (2016, result): “These observations were supported by the findings of Murphy and colleagues [46], who identified an increase in the Firmicutes:Bacteroidetes ratio in ob/ob mice and in mice fed a high-fat diet compared with lean mice.”
• 454 Pyrosequencing reveals bacterial diversity of activated sludge from 14 sewage treatment plants (2011, methodology): “They have also been used in other microbial diversity studies employing the PCR-based pyrosequencing method (Claesson et al., 2009; Jesus et al., 2010; Murphy et al., 2010).”
• Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease (2012, background): “In fact, the obese microbiome shows an increased ability to harvest energy from the diet [69], a feature that is transmissible between obese and non-obese mice despite similar energy intake [70].”