Selective neuronal vulnerability in Parkinson disease

By D. Surmeier, J. Obeso, G. Halliday. Nature Reviews Neuroscience, 2017

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Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction (2023, background): “This possible interaction is particularly relevant in cells with pacemaker activity, like the dopaminergic neurons of the substantia nigra pars compacta (SNpc), the neuronal population most severely affected in PD [31].”
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease. (2019, background): “Although injection into the STR does lead to transport of pathologic a-syn to SNc DA neurons, there is rarely LB pathology observed in the STR, making this an inaccurate mimic of PD progression (Surmeier et al., 2017).”
Past, Present, and Future of Parkinson’s Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy (2017, neutral): “Second, the distribution of LP in PD does not conform to a simple connectome rule.(254) Thus, the number or strength of synaptic connections with a seeding site does not dictate the probability of manifesting LP.”